CORDIS Project
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This project focuses on the mitochondrial outer membrane proteins and their roles in cellular functions such as energy regulation and apoptosis. The research aims to determine the structures of key protein complexes to provide insights into cancer biology and potential drug development.
To elucidate the biological role of the mitochondrial outer membrane (MOM), I propose to determine structures and functions of integral MOM protein complexes at atomic resolution, involving the three proteins VDAC, Bax and Sam.
These are key elements of vital cellular functions: the regulation of bioenergetics, mitochondrial biogenesis, apoptosis and cancer.
Our results will give new insights into the biology of eukaryotes and will open up new avenues for pharmaceutical applications.My research…
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