CORDIS Project
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This project focuses on understanding the structure and function of the kinetochore complex, essential for accurate chromosome segregation. It employs advanced techniques to analyze protein interactions and modifications that ensure proper cell division.
Accurate chromosome segregation in eukaryotes requires the assembly of the macromolecular kinetochore complex at centromeres to attach chromosomes to the mitotic spindle.
The kinetochore proteins are organized in stable subcomplexes that bind to dynamic microtubules and ensure fidelity of sister chromatid separation through feedback control.
Characterizing the kinetochore structure will significantly advance our understanding of chromosome segregation and how defects in this process can lead to…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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