CORDIS Project
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This project investigates the diverse roles of the Arp2/3 complex in human cells, focusing on its eight unique complexes. By analyzing their actin nucleation and disassembly properties, as well as their impact on cell migration, the research aims to clarify the molecular mechanisms underlying actin dynamics and cellula…
The actin cytoskeleton is a dynamic polymer system, that provides the driving force and structural support for the physical integrity of cells, and their interactions.
It also regulates many essential cellular processes, such as membrane trafficking and cell migration.
Not surprisingly, its malfunction results in a wide variety of syndromes and diseases.
Branched actin networks can only be assembled by the Arp2/3 complex, consisting of seven protein subunits.
Activated by nucleation promoting fa…
THE FRANCIS CRICK INSTITUTE LIMITED
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