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This research focuses on the role of a specific type of enzyme, HECT-type E3 ligases, in cancer biology. It aims to understand how these enzymes influence gene expression and DNA repair, potentially leading to new therapeutic targets for cancer treatment.
Cancer is a multifaceted disease in which dysregulated gene expression and other aberrant activities are crucial for neoplastic initiation, progression and tumor cell survival upon the treatment with anticancer modalities.One of the major mechanisms that regulate these processes is protein ubiquitination.
This modification can impose diverse effects on gene products–proteins, ranging from proteolysis to modulation of protein structure, localization and function.
Central components of ubiquitinat…
BAR ILAN UNIVERSITY
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