CORDIS Project
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This project explores the role of the cytokines IFN-β and IL-27 in treating multiple sclerosis by promoting regulatory T cells. It aims to clarify their signaling pathways and interactions, particularly focusing on the transcription factor IRF1 in a mouse model.
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS).
Activated autoreactive lymphocytes cause inflammation and subsequent damage in the CNS. IFN-β is used as the first line treatment of relapsing-remitting MS.
Yet, its mechanism of action remains obscure.
Recently published data indicate that IFN-β might suppress MS via production of IL-27. IL-27 then might suppress pro-inflammatory Th17 cells and induce generation of regulatory cells, namely Tr1 cells.
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