CORDIS Project
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This project investigates the molecular mechanisms behind mucus formation and its protective functions in the body. By studying mucin proteins, it aims to understand how their structure influences mucus properties, potentially leading to new treatments for various diseases.
Our bodies produce copious mucus daily to shield vulnerable epithelial cell surfaces in the lungs, intestines, and other organs.
Mucus is crucial for defense against pathogens and other environmental hazards, but the mechanisms by which mucus hydrogels assemble and execute their functions are poorly understood.
The main obstacle has been that the enormous, heavily glycosylated, and flexible mucin proteins constituting mucus are not readily amenable to structural and molecular approaches.
However…
WEIZMANN INSTITUTE OF SCIENCE
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