CORDIS Project
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This research aims to understand how transposons are silenced in eukaryotic genomes, particularly in Drosophila. It focuses on the piRNA pathway's role in controlling transposon activity and its implications for genome integrity.
All eukaryotic genomes contain mobile genetic elements called transposons.
They can be described as “endo-parasites” at the genomic level and come in a variety of classes including endogenous retroviruses.
The uncontrolled spread of transposons to new genomic sites poses a serious threat, e.g. due to insertional mutagenesis.
How the host functionally silences transposons remained mysterious for a long time.
Recently, the piRNA pathway, a germline specific RNAi pathway has been shown to be at the…
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
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