CORDIS Project
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This project investigates how the protease separase regulates the protein phosphatase Cdc55 during cell division. It aims to uncover the molecular mechanisms behind separase's role in promoting cell cycle progression and chromosome segregation at anaphase onset.
Activation of the protease separase at anaphase onset leads to cleavage of cohesin, thereby triggering chromosome segragation.
At the same time, an essential protease-independent function of separase promotes cell cycle progression out of mitosis.
In the host laboratory it has been recently shown that separase interacts with the Cdc55 isoform of protein phosphatase 2A (PP2ACdc55) at anaphase onset, downregulating it (Queralt et al. 2006).
However, the molecular nature of this non-proteolytic act…
CANCER RESEARCH UK LBG
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