CORDIS Project
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This project investigates how germ cells, essential for passing genetic information, are formed in mice. It focuses on the role of the Blimp1 protein in determining germ cell fate, utilizing engineered stem cells and transgenic mice to create a system for studying this process.
Germ cells serve the critical function of transmitting genetic and epigenetic information across generations in multi-cellular organisms.
An important attribute of the germ line is to generate the totipotent state.
Studies of this unique cell lineage are of wide general interest in the context of stem cells and mechanisms of pluripotency.
Relatively little is yet known about how germ cells are specified in mice.
Recent genetic studies showed that the transcriptional repressor Blimp1 is a critica…
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