CORDIS Project
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This project investigates how melanoma cells release proteins that suppress immune response, particularly focusing on a protein called PD-L1. By understanding the mechanisms behind this release, the project aims to develop strategies to enhance the effectiveness of cancer immunotherapy.
Harnessing the power of the immune system to treat cancer has long been a sought after goal of oncological research.
Immune checkpoint inhibitors, such as anti-programmed death receptor 1 (PD-1) blockade therapies, have now taken center stage.
However not all patients respond, highlighting gaps in our understanding of the mechanisms of tumour immunosuppression.
Upregulation of the PD-1 ligand (PD-L1) on tumour cells initiated this therapeutic direction, yet it is becoming clear that the modality…
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