CORDIS Project
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This project investigates the role of the Rac guanine exchange factor DOCK2 in T cell motility and activation within lymphoid tissue. By analyzing T cell interactions with dendritic cells, the research aims to clarify how DOCK2 influences T cell behavior based on peptide-major histocompatibility complex density.
Recent experiments using twophoton microscopy (2PM) of lymphocytes interacting with dendritic cells (DCs) loaded with cognate peptide – major histocompability complexes (pMHC) have uncovered their dynamic interactions inside lymphoid tissue of small rodents.
Depending on the amount of pMHC on the DC surface, motile T cells may either slowly integrate T cell receptor-mediated signals or immediately undergo long-term interactions with DCs.
Thus, motility and T cell activation inside lymphoid tissu…
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