CORDIS Project
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This project investigates the role of Wnt signaling in the process of vascular pruning, which is essential for proper blood vessel function. By studying this mechanism in mouse models, it aims to enhance understanding of vascular development and its implications for diseases like cancer and diabetic retinopathy.
A functional network of blood vessels is essential for all aspects of growth and organ function during embryonic development and adult life. A wide number of human disorders are related to vascular defects like cancer, diabetic retinopathy or stroke.
During vascular remodelling, superfluous blood vessels regress in a process named vascular pruning.
In contrast to the molecular mechanisms controlling vascular sprouting, vascular pruning has been less studied and very little is known about the cel…
CANCER RESEARCH UK LBG
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