CORDIS Project
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This study investigates dormant cancer cells in estrogen receptor alpha positive breast cancer that have undergone extended endocrine therapy. By analyzing tumor biopsies, the project aims to understand mechanisms of dormancy and resistance to treatment, ultimately seeking to improve patient outcomes through personaliz…
Endocrine therapy has clearly improved outcomes for estrogen receptor alpha positive (ER+) breast cancer patients, however the cumulative incidence of recurrence and death continues at a steady rate .
The majority of ER+ breast tumours treated with neoadjuvant letrozole in respond quickly and are generally excised after three months. A minority of tumours maintain a stable size by becoming dormant, these tumours continue to receive extended letrozole treatment and therefore represent the best cu…
THE UNIVERSITY OF EDINBURGH
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