CORDIS Project
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This project investigates the role of the Fragile X Mental Retardation 1 gene product, FMRP, in cognitive and behavioral abnormalities associated with Fragile X Syndrome. It aims to identify specific mRNA targets and protein partners of FMRP, as well as characterize neurochemical changes in affected mice to inform pote…
Mental retardation (MR) is a major cause of serious handicap, as well as an important medical and social issue, affecting 2-3% of the population.
The Fragile X Syndrome (FXS) is the most frequent hereditary cause of MR affecting 1/4000 males and 1/7000 females, due to the inactivation of the X-linked Fragile X Mental Retardation 1 gene (FMR1).
In FXS patients and the Fmr1 knock-out mouse, the lack of the gene product, the RNA-binding protein FMRP, induces behavioural and cognitive abnormalities,…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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