CORDIS Project
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This project investigates the molecular mechanisms of mammalian fertilization, focusing on the interactions between sperm and egg proteins. By utilizing advanced structural studies, it aims to create a comprehensive model of gamete recognition, which could enhance understanding and applications in reproductive medicine…
At the dawn of the 21st century, our knowledge of the molecular mechanism of mammalianfertilization remains very limited.
Different lines of evidence indicate that initial gamete recognitiondepends on interaction between a few distinct proteins on sperm and ZP3, a major component of theextracellular coat of oocytes, the zona pellucida (ZP).
On the other hand, recent findings suggest analternative mechanism in which cleavage of another ZP subunit, ZP2, regulates binding of gametesby altering the…
KAROLINSKA INSTITUTET
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