CORDIS Project
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This project investigates how neurons manage protein distribution to support synaptic functions and memory formation. By developing a theoretical framework, it aims to connect molecular dynamics with circuit functions, enhancing understanding of memory processes and related neurological disorders.
Proteins are the building blocks of life and neurons constantly need proteins to remain functional.
This is a formidable challenge because neurons must regulate dendritic protein numbers across hundreds of micrometers, and need to redistribute proteins quickly in response to any synaptic changes.
For example, long-term plasticity requires new proteins.
Yet, it is still a puzzle how the available pool of proteins is redistributed via diffusion or active trafficking and how synaptic protein number…
UNIVERSITATSKLINIKUM BONN
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