CORDIS Project
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This project investigates how cells transition between different states during embryonic development, focusing on the role of transcriptional noise in generating variability among genetically identical cells. By studying early mammalian embryos and embryonic stem cells, the project aims to uncover the molecular mechani…
The mechanisms powering the transition from one cell state to another are the central engine of embryonic development.
Genetic analysis over the last twenty years has provided us with a catalogue of genes and proteins that can be linked in linear and time dependent manners to specific states and transitions in this process.
However this picture, characterized by complex charts of univocal relationships between different genes, is static and rigid and contrasts with the plasticity displayed by ce…
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