CORDIS Project
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This project examines the role of tryptophan metabolism in the gut and its influence on health and disease. By identifying microbiota components affecting tryptophan pathways, it aims to uncover therapeutic targets for conditions linked to gut microbiota.
Tryptophan (Trp) is an essential amino acid required for protein biosynthesis and is also a biochemical precursor of metabolites which have major effects on mammalian physiology.
In the gastrointestinal tract, Trp metabolism can follow three major pathways, all of which are under the control of the gut microbiota: (i) the kynurenin pathway in immune and epithelial cells via indoleamine 2,3-Dioxygenase 1, (ii) the serotonin production pathway in enterochromaffin cells via Trp hydroxylase 1 and (i…
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