CORDIS Project
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The ModProtease project focuses on developing targeted cancer therapies by creating protease-antibody conjugates that can effectively address KRAS mutations. This involves high-throughput screening to identify effective protease variants that enhance the therapeutic effects of antibodies while minimizing side effects.
The integration of ModProtease with antibody-based systems represents a promising strategy for targeted cancer therapy, particularly in addressing the challenges posed by KRAS mutations.
These mutations are notoriously difficult to target directly with antibodies due to their involvement in intracellular signalling pathways and the development of resistance mechanisms.
Strategies to overcome these limitations could include the development of protease-antibody conjugates and these conjugates migh…
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