CORDIS Project
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This project investigates how specific chromatin modifications regulate gene expression in living cells. By using a novel epigenome editing platform, it aims to create a comprehensive dataset that elucidates the interactions between chromatin states and gene expression across various contexts.
Chromatin modifications are a key mechanism for regulating gene expression patterns in normal and disease settings.
Nonetheless, despite the ubiquity of epigenomics data, the causal functions of specific chromatin modifications have proved challenging to unravel.
This knowledge gap reflects limited approaches to dissect how chromatin modifications influence transcription quantitatively and context-dependently, across diverse genomic features or variants in any given cell-type.
Here, we propose t…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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