CORDIS Project
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This project simulates the development of joints in embryos, focusing on the formation of the synovial cavity and the shaping of cartilage surfaces. It combines mechanical and biological factors to enhance understanding of joint development, with potential applications in treating conditions like osteoarthritis.
Embryonic joint development is a complex process with several distinct stages.
The first step occurs in the cartilage anlage, where chondrocytes at the presumptive joint site stop proliferating and become compacted to form what is called the interzone.
From the interzone, the synovial cavity develops.
Once the cavity has been initiated, the surfaces of the opposing cartilage rudiments undergo gradual shape morphogenesis so that the ends of the two bones form a functioning, friction-minimising co…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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