CORDIS Project
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This project investigates the relationship between transcription and splicing in gene expression. By utilizing model-based data analysis, it aims to quantify the kinetics of splicing in genes, enhancing our understanding of how these processes interact during RNA processing.
Gene expression is the fundamental process that in all cells produces functional protein from a genomic DNA template using a messenger RNA (mRNA) intermediate.
Eukaryotic gene expression involves transcription--the polymerization of mRNA--and splicing--the removal of non-coding regions from the mRNA.
Recent evidence shows that nascent mRNAs are spliced while still being transcribed, not after completion of transcription, and that splicing machinery regulates transcription.
This cross-talk compli…
THE UNIVERSITY OF EDINBURGH
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