CORDIS Project
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This project investigates how modifications in transfer RNA (tRNA) processing affect protein quality control, which is crucial for cell function. By using genetic and biochemical techniques, it aims to understand the link between tRNA metabolism and protein aggregation, particularly in models of neurodegenerative disea…
Translation of the genetic code into functional proteins is a fundamental biological process essential for cell survival and function. tRNAs are critical in this process because they recognize the codons on the messenger RNA and bring the cognate amino acid to the nascent peptide.
To become functional, tRNAs undergo a series of processing steps and chemical modifications.
Recently, my host group discovered that cells lacking wobble uridine modifications in the tRNA anticodon display translationa…
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