CORDIS Project
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This project focuses on developing synthetic molybdenum complexes to mimic natural enzymes involved in human metabolism. By creating models for the molybdenum cofactor, the aim is to restore activity in patients with isolated sulfite oxidase deficiency, potentially leading to new treatment options.
Two rare but usually fatal diseases are caused by a failure at different levels of the multistep biosynthetic generation of the three human molybdenum dependent enzymes involved in metabolic processes.
In contrast to the more general Moco deficiency (MocoD) affecting all three enzymes, isolated sulfite oxidase deficiency (iSOD) cannot be treated yet.
The proposed project is primarily aimed at synthesising a large variety of molybdenum complexes that mimic the natural molybdenum cofactor of the r…
UNIVERSITAET GREIFSWALD
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Germany, Potsdam
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Ireland, Dublin
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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