CORDIS Project
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This research focuses on understanding the role of auxiliary proteins in the function of AMPA-type glutamate receptors, which are crucial for fast synaptic transmission in the brain. By investigating how these proteins affect receptor behavior, the project aims to uncover mechanisms relevant to neurological conditions.
AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory synaptic transmission in the brain.
The regulation of certain AMPARs (calcium-permeable;
CP-AMPARs) is relevant in synaptic plasticity, neuronal development and certain neurological diseases. AMPARs are regulated by transmembrane AMPA regulatory proteins (γ-2, -3, -4, -8;
TARPs), which affect the trafficking and also important biophysical properties of AMPARs.
Among them, we have recently demonstrated that TARPs increase single-…
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
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