CORDIS Project
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This project aims to unravel the mechanisms regulating mitochondrial gene expression, which is crucial for cellular metabolism and energy supply. By using innovative experimental approaches, it will explore mitochondrial RNA interactions, translation processes, and signaling pathways to enhance our understanding of how…
Mitochondrial gene expression is essential for cellular metabolism and energy supply since 13 core subunits of the OXPHOS system are encoded on the mitochondrial genome.
Despite its importance for cellular function, mitochondrial gene expression (mitoGE) and its regulation are not understood at a mechanistic level.
To this end, we demonstrated that mitochondrial translation is prone to regulation, responding to influx of nuclear-encoded proteins .
However, the mechanisms that regulate gene expre…
UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS
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