CORDIS Project
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This project investigates how the human parasite Toxoplasma gondii competes with host mitochondria for fatty acids during infection. It aims to understand the mechanisms by which mitochondria enhance fatty acid oxidation to limit parasite growth and explore their broader role in cellular defense against microbes.
Once a pathogen has eluded immune defences to establish a replicative niche in the cytosol, it requires nutrients to grow—the same nutrients that host organelles need for their biogenesis and to perform cellular metabolic processes.
The microbe must therefore compete with organelles for these nutrients..
This organelle-microbe competition for metabolites is a fundamental, but little understood aspect of the host–pathogen interaction. I recently defined one example of this competition, between mi…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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