CORDIS Project
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This project investigates the mitochondrial unfolded protein response (UPRmt) in mammalian cells, focusing on its effects on mitochondrial function, cytosolic homeostasis, and intercellular signaling. By utilizing advanced techniques, it aims to enhance understanding of how UPRmt influences cellular stress and disease…
Mitochondrial function is central for cellular metabolism and energy balance.
However, many diseases, including cancer and neurodegenerative diseases, affect mitochondrial function and proteostasis.
Upon mitochondrial protein misfolding, mitochondria activate the mitochondrial unfolded protein response (UPRmt) to restore proteostasis, a poorly characterized pathway in mammalian cells.
Notably, the effects of the UPRmt on its direct environment – mitochondria – and on cytosolic homeostasis remain…
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
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