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The MitoTROJAN project investigates the role of mitochondrial double-stranded RNA in neuronal susceptibility to mitochondrial dysfunction. By exploring the molecular mechanisms behind this response, the project aims to identify new therapeutic targets for mitochondrial diseases, particularly in energy-demanding neurons…
The symbiosis between the mitochondrion and the ancestor of the eukaryotic cell allowed cellular complexity.
Due to its archeobacterial origin, mitochondria has been posited as a potential source of molecules that can elicit cellular responses to pathogens.
Among other key functions, mitochondria generates most of the energy required by cells.
Alterations in components of the mitochondrial energy-generating machinery lead to primary mitochondrial disease (MD), a group of highly invalidating huma…
UNIVERSITAT AUTONOMA DE BARCELONA
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