CORDIS Project
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The MitoTransmitters project explores how mitochondria in axons respond to neuronal activity to maintain neurotransmitter levels, crucial for synaptic function. By combining advanced imaging and optogenetics, it aims to uncover the metabolic mechanisms that support brain health.
Released neurotransmitters must be replenished at extraordinarily fast time scales to support synaptic function, circuit physiology and behavior.
However, how axonal metabolism responds to the demands of neuronal activity to preserve neurotransmitter levels remains poorly understood.
While our understanding of the biochemical pathways for neurotransmitter synthesis is vastly detailed, very little is known about how these pathways are implemented in mammalian axons to preserve synaptic function a…
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