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The MITOsmORFs project aims to discover and characterize over 100 novel small proteins in mitochondria, which play crucial roles in cellular functions. It will utilize various biological techniques to analyze their localization and functions, enhancing our understanding of mitochondrial biology.
Mitochondria are essential organelles with crucial roles in cellular energy metabolism, Fe-S cluster biogenesis, signaling and apoptosis.
Mitochondrial dysfunction causes encephalomyopathy and neurodegenerative diseases.
Mitochondria possess a remarkably high content of small proteins compared to other cellular compartments.
About one third of the cellular proteins ≤15 kDa characterized to date are located in mitochondria.
Functional examples of such small proteins cover the whole mitochondrial…
UNIVERSITAETSKLINIKUM FREIBURG
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Germany, Freiburg
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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