CORDIS Project
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This project investigates how mitochondrial DNA (mtDNA) copy number is regulated in relation to cell volume, focusing on its impact on cell function and survival. By studying different eukaryotic species, the research aims to uncover the molecular mechanisms that maintain mtDNA homeostasis and their implications for ce…
Mitochondrial DNA (mtDNA) constitutes a substantial proportion of DNA in eukaryotes, and its regulation is critical not only for mitochondrial function but also for cell survival.
However, it is still unclear how mtDNA copy number is maintained during cell proliferation and how mtDNA copy number impacts on cell function.
Recently, my group showed that in budding yeast, mtDNA copy number is tightly linked to cell volume to maintain constant concentrations, providing an elegant and potentially con…
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
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