CORDIS Project
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This project investigates how mitochondrial function influences aging by examining the role of the mitochondrial prohibitin complex in cellular metabolism. Using C. elegans as a model, it aims to identify genetic pathways that regulate aging and mitochondrial health.
Mitochondrial defects are associated with aging and age-related pathology, but the molecular mechanisms regulating mitochondrial function during ageing are poorly understood.
The most relevant genetic pathway regulating ageing is the insulin/IGF-1 signalling (IIS) pathway.
The mitochondrial prohibitin (PHB) complex influences cellular metabolism and mitochondrial biogenesis, affecting ageing in opposite ways in wild-type animals and IIS-defective C. elegans mutants.
The aim of the proposed resea…
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