CORDIS Project
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This research focuses on the dynamics of the mitochondrial inner membrane, particularly the formation of cristae and their junctions. It aims to understand the molecular mechanisms involved in mitochondrial shape changes and their implications for human diseases.
Here, I propose to study the structure and mechanisms of the cellular machineries mediating the shape and dynamics of the mitochondrial inner membrane (IM).
The mitochondrial IM contains membrane invaginations called cristae.
These are connected by tubular openings, the crista junctions, to the remaining IM.
Mitochondrial shape constantly changes due to membrane fission and fusion events, and a balance of both processes is required for proper functioning of mitochondria.
Abnormal mitochondrial s…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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