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MITOSENSING investigates how mitochondria in specific neurons sense nutrients and regulate energy balance. The project aims to understand the role of these mitochondrial networks in metabolic disorders like obesity and type-2 diabetes.
Nutrient-sensing by POMC neurons is a critical process to monitor the metabolic status of the organism and to coordinate adaptive neuroendocrine, behavioural and metabolic effectors of energy balance.
Mitochondria, as central commanders of cellular energy production and primary sources of bioenergetic signals, are logical candidates to play a key role in metabolic control.
However, a comprehensive understanding of the mitochondria as nutrient-sensors and modulators of systemic energy homeostasis…
FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
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