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The MITOPORE project investigates the mechanisms of mitochondrial inner membrane pores that influence inflammation. By identifying the components and dynamics of these pores, the project aims to enhance understanding of their role in immune responses and develop potential treatments for inflammatory diseases.
Mitochondria are double-membrane organelles involved in key biological processes such as metabolism, calcium homeostasis and cell death. A major role of mitochondria in inflammation, a mechanism of innate immunity against tissue damage, has been recently recognized.
Due to their proteobacterial origin, certain mitochondrial matrix contents can act as potent immune agonists when exposed to the cytosol.
Hence, knowing the dynamics and molecular architecture of the mitochondrial pores mediating the…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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