CORDIS Project
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This project investigates the role of human PNPase, an enzyme in mitochondria, focusing on its dual function in RNA degradation and stabilization. By utilizing cryo-electron microscopy and biochemical methods, the research aims to enhance understanding of mitochondrial RNA transport and its implications for human healt…
Throughout the eukaryotic lineages, mitochondria are essential organelles that provide cellular metabolic power through oxidative phosphorylation.
In the mitochondrial intermembrane space resides an exoribonuclease highly conserved in the course of evolution:
PNPase.
Although the activity of this enzyme has been extensively studied, its function in this compartment is poorly understood. A clue to one of its potential functions has been provided by my recent findings on the bacterial PNPase, whic…
UNIWERSYTET WARSZAWSKI
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