CORDIS Project
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This project investigates how mitochondrial function influences the plasticity of brain circuits, particularly in the adult hippocampus. It aims to understand the role of mitochondria in neurogenesis and synaptic remodeling in response to experiences and metabolic demands.
A fundamental question in neuroscience is to reveal the energy constrains governing the plasticity of brain circuits.
Mitochondrial energy metabolism is increasingly recognized for regulating the activity and integrity of existing synaptic terminals, however it is unclear how changes in mitochondrial function are coupled with the generation of new neurons and the ensuing circuit remodelling, e.g. in response to experience or disease.
We have recently shown that a regionalized restructuring of th…
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