CORDIS Project
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This project explores the role of Melanoma Antigen (MAGE) genes in human diseases, particularly in cancer and neurodevelopmental disorders. It aims to understand the function of these genes through studies in the nematode C. elegans and mammalian neurons, focusing on mitochondrial integrity.
The Melanoma Antigen (MAGE) genes received increasing attention due to their roles in human diseases, mainly cancer and neurodevelopmental disorders.
The family includes over 25 genes in humans, characterized by a MAGE homology domain (MHD).
TypeI subfamily contains 3 gene clusters, which are silent in normal tissues, except in male germ cells and placenta.
TypeII subfamily contains un-clustered genes, expressed in embryonic and adult tissues, especially in the nervous system.
TypeII prote…
FOUNDATION FOR RESEARCH AND TECHNOLOGYHELLAS
IDRYMA TECHNOLOGIAS KAI EREVNAS
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