CORDIS Project
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This project investigates the role of mitochondrial dynamics in the transition of melanoma cells from a mesenchymal to an amoeboid state, which enhances their ability to invade tissues. By employing advanced techniques, it aims to elucidate how mitochondria influence cancer cell motility and potentially inform new ther…
Tumor cell migration and invasion represent the foundation of cancer metastasis.
It is therefore critical to better understand themechanisms driving a specific subset of tumor cells to invade nearby tissues.
Invasive cells are known to have an undifferentiated,mesenchymal-like state.
However, under specific microenvironment conditions, mesenchymal cells become amoeboid, through aprocess known as the mesenchymal-to-amoeboid transition (MAT).
Paradoxically, it is not the mesenchymal cells that are…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School
United States, Boston
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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