CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project explores the role of Parkin, an E3 ubiquitin ligase, in regulating mitochondrial function and neuronal survival. It focuses on how Parkin-mediated ubiquitination of Mitofusin affects mitochondrial interactions with the endoplasmic reticulum and cell death pathways.
Parkin, an E3 ubiquitin ligase and a Parkinsons's disease related gene, translocates to impaired mitochondria upon mitochondria intoxication and drives their elimination via autophagy, a process known as mitophagy.
Mitochondrial pro-fusion protein Mitofusin (Mfn) was found to be a target for Parkin mediated ubiquitination.
In absence of Parkin, Mfn fails to be ubiquitinated, thus accumulates in the mitochondria, leading to increased mitochondria fusion.
The host laboratory discovered that Mfn2 h…
UNIVERSITE DE GENEVE
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
