CORDIS Project
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This project aims to understand the structural dynamics of chromosomes during cell division. By using advanced imaging techniques, it investigates how chromosomes fold and unfold, providing insights into the mechanisms that ensure accurate genetic segregation.
Mitosis is a fundamental biological process every cell undergoes at least once.
It requires a dynamic and dramatic restructuring of the genome from extended interphase chromatin to compact individual mitotic chromosomes capable of faithful segregation.
Altered nucleosome interactions, phase separation and loop extrusion have all been proposed to play important roles in shaping mitotic chromosomes.
However, what the internal architecture of single mitotic chromosomes is, and how this architecture…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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