CORDIS Project
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This project explores the link between chronic stress, mitochondrial function, and vulnerability to depression. By studying the glucocorticoid receptor's role in stress responses, it aims to identify mechanisms that contribute to depression and potential therapeutic targets.
Depression is considered as a common mental illness worldwide affecting around 350 million people.
Chronic stress is a major risk factor for its development.
Interestingly, individuals can differ in the way of coping with chronic stress and are either prone (vulnerable) or resistant (resilient) to develop depression.
High anxiety-trait is a vulnerability factor to develop stress-induced depression.
Furthermore, it was also linked with mitochondrial dysfunction in the nucleus accumbens and in the…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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