CORDIS Project
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This project explores the mechanisms behind mitochondrial DNA deletions, particularly in relation to neurodegenerative diseases. It aims to identify factors involved in DNA repair processes and investigate potential therapeutic pathways to prevent these deletions.
Mitochondrial DNA (mtDNA) deletions accumulate in aged post-mitotic tissue and in individuals with neurodegenerative diseases, leading to local energy defects.
Understanding the mechanism of mtDNA deletion formation is an essential step in trying to prevent their occurrence.My hypothesis is that mtDNA deletions occur during mtDNA repair via a double strand break (DSB) repair pathway. I will address the different components of this hypothesis by mechanistic studies of cell lines derived from pati…
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UGOT - GOETEBORGS UNIVERSITET/UNIVERSITY OF GOTHENBURG
Sweden, Goeteborg
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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