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MitoCyto investigates the behavior of mitochondrial precursor proteins in the cytosol, aiming to understand their interactions and effects on cellular health. By employing innovative techniques from various scientific fields, the project seeks to uncover mechanisms related to aging, neurodegenerative diseases, and canc…
Mitochondria are made of 800 to 1500 proteins which represent up to 30% of the cellular mass.
Owing to their post-translational mode of import, mitochondrial precursor proteins explore the cytosol before they are imported into mitochondria.
These reactions are of utmost importance for cellular functionality since cytosolic precursors pose a major threat of cellular proteostasis and are major drivers in aging and for the pathogenesis of neurodegenerative diseases.
Still, the biology of cytosolic…
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