CORDIS Project
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This project investigates the mitochondrial calcium uniporter (MCU), focusing on its biological role, structure, and potential for pharmacological targeting. It aims to understand MCU's function in cellular responses and its implications for diseases related to mitochondrial calcium dysregulation.
Mitochondrial Ca2+ homeostasis is an important component of the calcium-mediated cellular response to extracellular stimuli.
It controls key organelle functions, such as aerobic metabolism and the induction of apoptotic cell death, and shapes the spatio-temporal pattern of the cytosolic [Ca2+] increase.
While its physiological and pathological relevance is now fully appreciated, lack of molecular insight has severely limited mechanistic understanding and pharmacological targeting.
We have now id…
UNIVERSITA DEGLI STUDI DI PADOVA
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