CORDIS Project
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This project explores how certain bacteria, specifically Staphylococcus aureus and Streptococcus mitis, adhere to human platelets through interactions with a receptor called CD36. By studying this binding mechanism, the research aims to better understand the development of infective endocarditis and the immune system's…
The binding of microorganisms to human platelets is a central process in the pathogenesis of Infective endocarditis.
The deletion of genes encoding platelet adhesins in Staphylococcus aureus and Streptococcus mitis, two leading causes of Infective endocarditis, has been shown to result in a reduction in virulence in animal models of infective endocarditis.
While investigating the S. mitis virulence factors that are responsible for the adherence of bacterial cells directly to platelets we identif…
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
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