CORDIS Project
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This project examines how errors during cell division contribute to cancer development by exploring non-genetic factors. It focuses on the effects of mitotic errors on cellular behavior and genome function, aiming to uncover mechanisms that drive tumorigenesis.
One of the holy grails in cancer biology is to understand how genomic instability, a hallmark source of mutagenesis, arises.
However, surprisingly little is known about non-genetic drivers of tumorigenesis.
My proposal will delve into the old question of how Mitotic Errors and nuclear Abnormalities (MitErrA) affect cellular homeostasis, from a fresh perspective: the elucidation of non-genetic effects on genome function and cellular adaptation.I recently discovered that micronuclei, a prominent t…
INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH
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