CORDIS Project
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The MitCare project aims to develop effective therapies for mitochondrial disorders by exploring pharmacological stimulation of mitochondrial biogenesis and gene delivery methods in mouse and pig models. This research addresses the challenges of ATP deficiency and aims to improve understanding and treatment of mitochon…
Mitochondria are the major source of ATP, synthesized by the mitochondrial respiratory chain (MRC) through the process of oxidative phosphorylation. ATP deficiency leads to cellular dysfunction and ultimately death.
In mammals, 13 mitochondrial DNA (mtDNA)-encoded subunits interact with over 70 nuclear-encoded subunits to form four of the five MRC complexes.
Many additional factors are essential for the regulation of MRC activity, and the maintenance and expression of mtDNA.
As a result, genetic…
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Italy, CREMONA
Type: SME
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: Yes
United Kingdom, LONDON
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
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