CORDIS Project
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This project focuses on developing a gene therapy system called miRTo, which uses natural microRNAs to induce cell death specifically in T-cell acute lymphoblastic leukemia (T-ALL) cells. The goal is to create a safer and more effective treatment for T-ALL patients while allowing for adaptations to target other cancers…
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy.
Although outcome has improved throughout the years with the use of combined chemotherapy, the aggressive regimens required for treatment efficacy often lead to significant short- and long-term side effects.
Moreover, a significant fraction of T-ALL patients relapse, which have extremely poor prognosis.
The current project aligns with the core goal of our ERC Consolidator Grant IL7sigNETure (CoG-648455) to gene…
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